We define vaccine candidates using our iterative epitope screening technology. We apply the knowledge of pathogen host-immune interactions to pin-point protective antigens.

We use distinct vaccine delivery methods to achieve a maximum protection for different pathogens. Our vaccine delivery pipelines include self-replication RNA, probiotic, DNA, and algal antigen delivery systems.

Since antimicrobial resistance in microbial pathogens poses an increasing and ever-present danger, we have sought non-toxic bioactive compounds that can interfere with the bacterial growth and virulence of economically important pathogens.

Gut health plays a crucial role in maintaining an individual’s health. We are developing nutrition-based interventions to address some of the essential gastrointestinal ailments of humans and animals.

The frequency of coccidiosis and chicken necrotic enteritis outbreaks is increasing as the use of antibiotics in animal feed is reduced or eliminated. To address this problem, we set out to produce a dual vaccine for these two pathogens, both of which cause significant economic loss. Using our vaccine technology, we have developed a chicken necrotic enteritis vaccine that shows efficacy in our preliminary experimental challenge model. We are currently engineering this vaccine in the context of a probiotic which will deliver anti-clostridial properties.

Clostridium perfringens types A and C and Clostridium difficile affect piglets early in life. Clostridium perfringens type C vaccine for sows can protect piglets from this strain, but this vaccine does not offer any cross-protection. Due to the genetic diversity within Clostridium perfringens type A and Clostridium difficile strains, broadly protective vaccines are required. We have used our vaccine technology to find the common protective antigens across a genetically diverse set of strains. We generated a dual vaccine for sows that is designed to transfer protection to piglets. We are raising funds to conduct challenge studies to address C. perfringens and C. difficile infections in piglets.